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Date: July 5, 2011Roundtable ID: CV5580Citation: Med Roundtable Cardiovasc Ed. ; 2(3): 158 - 166.
Lipids and Guidelines -- "Let Me Be Simple-Minded Doctor!!" LDL-C Less Than 70 mg/dL and Pay Attention to HDL
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Summary:
Dr. Daniel Rader from the University of Pennsylvania School of Medicine moderated the topic "Lipids and Guidelines - 'Let Me Be Simple Minded Doctor!!' LDL-C Less Than 70 mg/dL and Pay Attention to HDL" with Drs. Roger S. Blumenthal from the Johns Hopkins University School of Medicine and Anne C. Goldberg from Washington University School of Medicine participating.
- The discussion focused primarily on:
- (1) aggressive targeting of low-density lipoprotein in high-risk patients;
- (2) the challenges of moving patients to an LDL cholesterol level <70 mg/dL, even with combination statin therapy;
- (3) the effect of results from recent trials such as AIM-HIGH and the recent warning on high-dose simvastatin on clinical practice;
- (4) the ideal LDL level in high-risk patients for primary or secondary prevention;
- (5) managing cholesterol levels in high-risk patients who cannot tolerate high-dose statins;
- (6) the potential impact of generic atorvastatin;
- (7) the role of risk scores such as Framingham on LDL goal for primary prevention;
- (8) the role of coronary calcium scores, hsCRP, and Lp(a) levels on management approaches;
- (9) the importance of non-HDL cholesterol and HDL cholesterol on risk and the implications for treatment; and
- (10) the impact of aggressive lifestyle approaches on raising HDL levels.
- (Med Roundtable Cardiovasc Ed. 2011;2(3):158-166) ©2011 FoxP2 Media, LLC
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Compounds:Trials:
PROVE IT-TIMI 22, ACCORD-Lipid, AIM-HIGH, IMPROVE-IT, JUPITER, ARBITER-6 HALT, HATS, HPS2-THRIVE, AFCAPS/TexCAPS
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